Sepsis, despite the range of modern treatments available, is still associated with a high mortality rate. The ICE therapy fights sepsis by using immune cells provided by healthy donors. Granulocytes are utilized in this process. The donor’s granulocytes partially take over missing functions from the patient’s own dysfunctional immune cells. Inflammatory substances/agents are removed from the patient’s plasma using phagocytosis. Furthermore, immune stimulating substances are produced and released into the patient. This is carried out by an extracorporeal blood circulation procedure, a plasmapheresis and a cell circuit. The granulocytes circulate within the extracorporeal circuit and are not introduced into the patient. The separated plasma obtained from the patient’s blood is continuously transferred into this circuit. Following a period of sufficient contact between the plasma and the granulocytes the treated plasma is once more separated and reintroduced to the patient’s venous blood. This treatment can last for several hours.
The aim of the current development process is to create a simple, compact therapy system.