Sepsis diagnostics

For more than 100 years sepsis has been defined mainly by four criteria that have been specified at a consensus conference in 1992: Two out of the following four criteria have to be fulfilled in reaction to an infection.

Temperature >38°C or Heart rate > 90 per min
Breathing > 20 per min
White blood cell count >12000 or

This of course is only the common picture for many different appearances of sepsis and by far too limited to identify the actual stage of sepsis the patient is in. Therefore, new parameters have been introduced like interleukin 6, procalcitonin, and the number of molecules of HLA-DR on monocytes that all correlate somehow with the severity of sepsis. However, the informative value of these new parameters is also limited.

In contrast, the newly developed immunoassay of ARTCLINE uses active immune cells as a biosensor. This results in a signal integration of many different influences onto the cells, having cellular functions as a read-out.

The patented test is currently further validated in clinical tests and is being offered to interested customers as diagnostic service.